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Patients with Low Drug Levels or Antibodies to a Prior Anti–Tumor Necrosis Factor

Updated: Mar 15, 2021

Patients with Low Drug Levels or Antibodies to a Prior Anti–Tumor Necrosis Factor Are More Likely to Develop Antibodies to a Subsequent Anti–Tumor Necrosis Factor

AUTHOR CONTRIBUTIONS: All authors have approved the final draft submitted. Study concept, design, and supervision: NVC, AJ, ASC; data acquisition: LO, LY, AJ; statistical analysis: NVC, LO, LY, AJ; drafting of manuscript: NVC, FR; interpretation, critical revisions, and final approval: all authors

FUNDING SUPPORT: TDM testing was performed by Prometheus Biosciences. KP was funded by the Ruth L. Kirschstein NRSA Institutional Research Training Grant (5T32DK007760-18). NVC holds a Research Scholar Award from the American Gastroenterological Association.


NVC : research grants from R-Biopharm, grants and personal fees from Takeda and UCB, personal fees from Celltrion and Prometheus. MTA : Consulting/Advisory Board of Boehringer Ingelheim, Gilead, Landos Biopharma, Teaching/Lecturing for Cornerstones Health, Inc., Focus Medical Communications, Imedex, Janssen Pharmaceuticals, Grants from Pfizer, Prometheus Laboratories Inc., Takeda Pharmaceuticals, SF : no disclosures, KP : no disclosures, FR : Consulting or AdBoard for Agomab, Allergan, AbbVie, Boehringer-Ingelheim, Celgene, Cowen, Genentech, Gilead, Gossamer, Guidepoint, Helmsley, Index Pharma, Jannsen, Koutif, Metacrine, Morphic, Pfizer, Pliant, Prometheus Biosciences, Receptos, RedX, Roche, Samsung, Takeda, Techlab, Thetis, UCB, Grants from NIH, Helmsley Charitable Trust, Crohn’s and Colitis Foundation, Department of Defense, UCB, Pliant, BMS, Pfizer, Boehringer Ingelheim, Morphic, Kenneth Rainin Foundation, MSS : Speaker, advisory board member, research and/or consultant for AbbVie, Janssen, Prometheus, Takeda, Pfizer, Ferring, Gilead, Amgen, Novartis, Lilly: RK : Speaker, advisory board member, and or clinical investigator for AbbVie, Encycle, Gilead, Innomar, Janssen, Lilly, Merck, Pfizer, Pendopharm, Robarts Clinical Trials, Roche/Genetec, Shire, Takeda., LO , LY , and AJ are employees of and own stock options for Prometheus Biosciences, ASC : Consulting Abbvie, Janssen, Takeda, Pfizer, Samsung, Arena, Prometheus, Bacainn; Research support Inform Diagnostics

Patients With Low Drug Levels or Antibod
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